In the univariable analysis, older age (>80 years old vs <60 years old: HR = 2.98, p < 0.001), male gender (HR = 1.33, p = 0.012), diagnosis before 2000 (HR = 1.33, p = 0.014), advanced stage (HR = 1.40, p < 0.001), not receiving treatment with surgery (HR = 1.41, p = 0.003) and a histologic subtype of DLBCL (HR = 2.24, p = 0.005) were associated with unfavorable survival for patients with PRL (Table 3). The gene discussed is PRL; the disease is diffuse large B-cell lymphoma.