More importantly, they had higher levels of fasting plasma insulin (234.0 ± 4.9 vs. 118.7 ± 3.3 pmol L−1; unpaired Student’s t test p = 6.1 × 10−14) causing a significant increase of homeostatic model assessment of insulin resistance (HOMA-IR) score (80.0 ± 2.1 vs. 34.9 ± 1.6; p = 8.4 × 10−13) resembling a model of peripheral insulin resistance (Fig. 1d, e). The gene discussed is INS; the disease is Insulin resistance.