BDNF and Cognitive impairment: To dip inside the critical role of BDNF signaling alteration in HFD-dependent mother to offspring transmission of cognitive impairment, we intraperitoneally (IP) injected HFD-fed female mice with BDNF (3 times per week for 4 weeks) as long as they fed HFD until the breeding (hereinafter named F0 HFD BDNF).