We identified one frameshift and three missense QRS variants where we had identified non-coding QRS variants previously in our study: in CTNNA3, NKX2-5, RNF207 and TBX5. We recently reported the missense variant p.Phe145Leu in NKX2-5 as causing cardiomyopathy and arrhythmias36. The gene discussed is TBX5; the disease is cardiomyopathy.