Rs11166990[A] upstream of PTK2 (coding for focal adhesion kinase), which also associates with the R amplitude in lead V1, associates with hypertension (MAF = 48%, OR = 0.97, P = 1.1 × 10−6), aortic valve stenosis (OR = 0.92, P = 2.1 × 10−4), and is known to associate with reduced risk of AF. This evidence concerns the gene PTK2 and atrial fibrillation.