RYR2 and heart disorder: Variants in some of these genes have been described by OMIM as causing autosomal dominant heart conditions (MYBPC3, MYH6, MYH7, CTNNA3, RBM20, RYR2, SCN5A) or associated in GWAS with heart diseases (CASQ2, MYH7B, MYO18B, SYNPO2L, TBX5, TRIM63)27,42,43, resting heart rate (CCDC141, FHOD3)44 or non-QRS ECG parameters (ALPK3, RNF207)45,46.