C.927-2A>G in MYBPC3 (MAF = 0.18%) associates with cardiomyopathy, heart failure, ventricular tachycardia and atrial fibrillation (AF), and p.Arg721Trp (MAF = 0.34%) in MYH6 with sick sinus syndrome (SSS), AF and coarctation of the aorta. This evidence concerns the gene MYBPC3 and sick sinus syndrome.