We found that IRE1 deficiency markedly rescued α-Syn-evoked retinal degeneration, as shown by 70%, 72%, and 62% of intact ommotidia, respectively, in retina from GMR-Gal4 > α-SynWT; Ire1-Ri, GMR-Gal4 > α-SynA30P; Ire1-Ri, and GMR-Gal4 > α-SynA53T; Ire1-Ri flies at 30 days of age (Fig. S1a, b). This evidence concerns the gene LGALS4 and retinal degeneration.