By contrast, at 30 days of age, overt retinal degeneration, as manifested by the apparent loss of photoreceptor neurons along with vacuole formation, was observed in the GMR-Gal4 > α-SynWT, GMR-Gal4 > α-SynA30P and GMR-Gal4 > α-SynA53T flies when compared to the GMR-Gal4 > + control line (Fig. S1a). This evidence concerns the gene LGALS4 and retinal degeneration.