A reduction in the number of mature dendritic spines in a triple-transgenic mouse model of AD (3 × Tg-AD: PS1 (M146V), APP (Swe), tau (P301L)) and increased Aβ levels due to the augmentation of amyloid-β protein precursor processing58 have been observed in response to short-term stress. This evidence concerns the gene MAPT and Alzheimer disease.