RBPJ and atherosclerosis: Interestingly, in the Apoe−/− mouse atherosclerosis model, this vascular inflammatory phenotype in the atheroma-prone regions of the carotid artery was demonstrated to depend on the endothelial expression of the Notch effector recombination signal binding for immunoglobulin kappa J region (RBPJ) (47), but the microbiota-dependent impact on endothelial pathways promoting leukocyte adhesion in atherosclerosis needs further investigation.