In line with this, we observed the upregulation of AKT1 signaling with the enhancement of ID1 expression in coexisted ASXL1 and RUNX1 mutant cells that would contribute to the leukemogenesis in a subset of patients with CMML or CML myeloid BC (Fig. 8). This evidence concerns the gene RUNX1 and chronic myelogenous leukemia, BCR-ABL1 positive.