In line with this, we observed the upregulation of AKT1 signaling with the enhancement of ID1 expression in coexisted ASXL1 and RUNX1 mutant cells that would contribute to the leukemogenesis in a subset of patients with CMML or CML myeloid BC (Fig. 8). The gene discussed is ASXL1; the disease is chronic myelomonocytic leukemia.