Three PD-L1 inhibitors (Atezolizumab, Avelumab, Durvalumab) and two PD-1 inhibitors (Pembrolizumab, and Nivolumab) have been approved by the U.S. Food and Drug Administration (FDA) for the treatment of melanoma, lymphoma, non-small cell lung cancer, liver cancer, bladder cancer, head and neck cancers, and kidney cancer. Here, CD274 is linked to melanoma.