Here, we found that MEIS2 hypermethylation had diagnostic potential for PC with a high AUC (AUC assay 1/2, 0.814/0.917), comparable to AUCs reported for previously published candidate methylation markers for PC (AUCs 0.794–0.980) [5, 6, 8, 9, 11, 38]. Here, MEIS2 is linked to pachyonychia congenita.