Although epigenetic silencing of MEIS2 has also been described in lung and hepatocellular carcinoma cell lines as well as colorectal cancer [39–41], the function of MEIS2 in other cancers remains unclear and may be highly disease-specific as MEIS2 is downregulated in some cancers and upregulated in others [13]. The gene discussed is MEIS2; the disease is hepatocellular carcinoma.