Moreover, higher numbers of FOXP3+ Treg are related with a better outcome in follicular lymphoma (FL), germinal center-like diffuse large B cell lymphoma (DLBCL) and classical Hodgkin lymphoma (CHL), but have a negative prognostic association in non-germinal center-like DLBCL; and cases of FL with transformation to DLBCL are associated with marked reduction of FOXP3+ Treg in the tumor microenvironment [22, 23]. The gene discussed is FOXP3; the disease is classic Hodgkin lymphoma.