This data supports the relevance of studying the expression of PD-L1 on tumor cells of pc-CD30-LPD, since one of the pathways to down-regulation of effector anti-tumor T-cell activity is by PD-1+ follicular helper T-cells binding to their ligand PD-L1 [13, 17]. The gene discussed is TNFRSF8; the disease is neoplasm.