Distinct and sometimes opposing roles of FOXP3+ Tregs have been described in the literature: (a) suppressor Tregs, which suppress anti-tumor CD8+ cell-mediated immune responses, similar to the ones found in solid tumors; (b) malignant Tregs in the form of FOXP3+ T-cell lymphomas such as adult T cell leukemia/lymphoma; (c) direct tumor-killing Tregs - some lymphoma cells can be target cells for Tregs suppressive cytotoxicity, suggesting that Tregs can be tumor cell killers; and (d) incompetent Tregs when the number of FOXP3+ Tregs are significantly reduced, representing resting Treg [24]. The gene discussed is CD8A; the disease is T-cell non-Hodgkin lymphoma.