The reduced distant metastatic potential was reflected in the lungs, which emitted less bioluminescent signal in animals implanted with shGal1 tumor when compared to those implanted with shCtrl tumor (P < 0.01) (Fig. 2h) and thus suggesting that Gal-1 in HCC enhances the ability of tumor cells to metastasize to the lungs. Here, LGALS1 is linked to neoplasm.