The significant overexpression of Gal-1 in these cancers including cholangiocarcinoma (CHOL), diffuse large B-cell carcinoma (DLBCL), esophageal carcinoma (ESCA), glioblastoma (GBM), head and neck squamous cell carcinoma (HNSC), pancreas adenocarcinoma (PAAD) and in thymoma (THYM). This evidence concerns the gene LGALS1 and head and neck squamous cell carcinoma.