Comparison with recently published whole genome bisulfite sequencing data (WGBS) for prostate cancer [21] revealed that about 60% of the top DMS (associated with C11orf87, CCT8L2, CD84, CTSC, DOK5, FCRL1, LCE3A, MMP16, MOS, OR5W2, PEG3/ZIM2 and SLC1A6) were located in so-called partially methylated domains (PMDs) (Additional file 6: Figure S4). This evidence concerns the gene MMP16 and Familial prostate cancer.