First, IGHV SHMhigh was associated with significantly longer OS in DLBCL patients and longer OS and PFS in DLBCL patients without MYC/BCL2 translocations, which is reminiscent of the favorable PFS and OS incrementally associated with IGHV% deviation in CLL patients [45]. The gene discussed is MYC; the disease is diffuse large B-cell lymphoma.