Second, compared with IGHV, IGK/LV had less SHM, but IGK/LV SHMhigh was associated with significantly poorer OS and PFS and high PD-1 expression in CD4+ T cells and PD-L1 in natural killer cells in GCB-DLBCL, even though FW3-derived MHC-II neoantigens with rare neoepitopes were significantly higher in IGK/LV SHMhigh DLBCL compared with IGHV SHMhigh DLBCL (4.4 vs 2 per patient) and IGH/K/LV SHMlow DLBCL (1 per patient). Here, CD4 is linked to diffuse large B-cell lymphoma.