BCL2 and diffuse large B-cell lymphoma: In summary, clonal IGHV SHMhigh had favorable prognostic effect in patients with DLBCL without BCL2/MYC translocation, whereas IGHV ongoing SHM and clonal IGK/LV SHMhigh had adverse prognostic effects in DLBCL and GCB-DLBCL patients, respectively.