Compared with IGK/LV SHMlow patients, IGK/LV SHMhigh patients had significantly higher PD-L1 expression in natural killer cells (P = 0.037; Fig. 5c) and higher CTSL1 (lysosomal protease genes cathepsin L [43]) mRNA expression in GCB-LDBCL (P = 0.038; Additional file 1: Figure S9e), but significantly lower B-cell PD-1 expression (P = 0.03) in ABC-DLBCL (Additional file 1: Figure S9f). The gene discussed is PDCD1; the disease is diffuse large B-cell lymphoma.