When partitioning DLBCL into GCB and ABC subtypes, the favorable prognostic effect of IGHV SHMhigh was significant in ABC-DLBCL and marginally significant in BCL2-R− and MYC-R− GCB-DLBCL (for OS, P = 0.059 and 0.066, respectively; Additional file 1: Figure S5c-d). This evidence concerns the gene BCL2 and diffuse large B-cell lymphoma.