Intriguingly, the expression of either the conventional anti-tau intrabody or the intrabody fused to ubiquitin harboring a K48R mutation was ineffective in delaying or eliminating tauopathy in in vivo which contrasted with our data in HEK293t cells and primary neuronal cultures (Figs. 1 and 2). The gene discussed is MAPT; the disease is tauopathy.