In peripheral blood of both B cell non-Hodgkin lymphoma(B-NHL) and T-NHL patients, M-MDSCs (CD14+HLA-DRlow/− ± CD120blow) were observed accumulating compared with healthy donors, which were correlated with advanced lymphoma stage, refractory state, higher International Prognostic Index score (IPI), and disease-free survival (DFS). The gene discussed is CD14; the disease is non-Hodgkin lymphoma.