The high expression of BMI-1 is correlated with poor prognosis so that BMI-1 is considered as a viable therapeutic target in some malignancies, such as colorectal cancer [18, 19], ovarian cancer [20, 21], prostate cancer [22, 23], non-small lung cancer [24], breast cancer [25, 26]. The gene discussed is BMI1; the disease is colorectal cancer.