We propose that this characterises and establishes a new MCPyV positive MCC-subtype, unveils a novel MCPyV oncogenic mechanism and potential oncogenic function for MCPyV large T-antigen, identifies TrkAIII as novel potential therapeutic target and provides a rational for the use of Trk inhibitors, such as Larotrectinib, in the treatment of this MCPyV positive TrkAIII expressing tumour subtype. This evidence concerns the gene NTRK1 and Merkel cell skin cancer.