Although the influence of TrkAIII on MCC behaviour remains to be elucidated, TrkAIII oncogenic activity, confirmed by its capacity to transform NIH3T3 cells and promote oncogenic behaviour in neuroblastoma models, has been reported to involve re-localization of this compromised receptor to pre-Golgi membranes, centrosomes and mitochondria. This evidence concerns the gene MCC and neuroblastoma.