EGF and triple-negative breast carcinoma: The triple-negative breast cancer cell line MDA-MB231 induced HUVEC cell to generate tubes as efficiently as the growth factors VEFG, EGF, and FGF containing EBM-2 medium (46 vs. 51 tubes for MDA-MB231-conditioned medium and EBM-2 medium, respectively, Fig. 1a, b).