The 104 week DURATION-8, 24 week AWARD-10, and 30 week SUSTAIN 9 trials demonstrated that simultaneous initiation of GLP-1 RA exenatide and SGLT2i dapagliflozin, or addition of GLP-1 RAs dulaglutide and semaglutide to open-label SGLT2i, durably improved glycemic control and cardiovascular risk factors without increasing the risk of hypoglycemia [7–10]. This evidence concerns the gene GCG and Hypoglycemia.