Consistently, GLK-IQGAP1 interaction and GLK-induced IQGAP1 Ser-480 phosphorylation are detectable in cancer tissues and metastatic cancer cells of human lung cancer patients; this interaction and IQGAP1 phosphorylation are correlated with poor survival of lung cancer patients [26]. Here, MAP4K3 is linked to metastatic malignant neoplasm.