GRK5 and lung cancer: Figure 1 shows the heatmap of the DEGs, illustrating a clear separation of tumor and non-tumor samples in two expression clusters. Many of them are known key players in lung cancer, for instance G Protein-Coupled Receptor Kinase 5 (GRK5) [30], Solute Carrier Family 46 Member 2 (SLC46A2) [31], and Collagen Type XI Alpha 1 Chain (COL11A1) [32] function as oncogenic factors in lung cancer.