Phosphorylation of Tau at multiple sites is regulated by several kinases, most notably GSK3β (Tau ser205, Tau ser231, Tau ser396; in AD and control brains), PKA (Tau ser214, Tau ser262, Tau ser409; only in AD brains), and CaMKII (Tau Ser212, Tau Ser214, Tau Ser262, Tau Ser356, Tau Ser416; Table 1) [27,32,33,34,35]. This evidence concerns the gene MAPT and Alzheimer disease.