In Figure 1A we demonstrate that p-Ser473 Akt, p-Thr408 Akt, p-Ser2448 mTOR, and Thr46/47-4E-BP1 levels were highly expressed in GBM cell models, whereas in Figure 1B RES529 inhibited -Ser473 Akt (upstream enzyme) and pSer235/236-S6 (downstream enzyme) with similar IC50 values in U87MG (as a model for differentiated GBM cells) and CSCs-5 (as a model of cells with stem-like phenotype). This evidence concerns the gene MTOR and glioblastoma.