AKT1 and neoplasm: One such of these inhibitors is the small molecule 8-(1-Hydroxy-ethyl)-2-methoxy-3-(4-methoxy-benzyloxy)-benzo[c]-chromen-6-one named RES529 (previously Palomid 529 or P529) RES529 markedly reduces the signaling mediated by phosphorylation of Akt (S473) [41,42,43,44] and in preclinical in vivo murine models was able to inhibit angiogenesis, vascular permeability, and tumor growth [41,44].