RPS6 and neoplasm: These pathways participate to the PI3K/Akt/mTOR activity regulating in turn tumor cell growth/viability, drug resistance, and angiogenesis [32,33] through p70S6 kinase (p70S6K), ribosomal S6 protein (RPS6), and eukaryotic initiation factor 4E-binding protein 1 (4EBP1) [34,35].