In a study by Scartozzi et al. [36], aunivariate analysis of VEGF-A alleles C of rs25648, T of rs833061, C of rs699947, C of rs2010963, VEGF-C alleles T of rs4604006, G of rs664393, VEGFR-2 alleles C of rs2071559, C of rs2305948 showed significant predictive factors of PFS and OS in sorafenib-treated HCC. The gene discussed is VEGFA; the disease is hepatocellular carcinoma.