The role of SOX2 mRNA expression and copy number alterations in OSCC was investigated by analyzing a subset of 172 OSCC patients from the TCGA Head and Neck Squamous Cell Carcinoma (HNSCC) cohort [23] using the platform cBioPortal (http://cbioportal.org/) [24]. The gene discussed is SOX2; the disease is head and neck squamous cell carcinoma.