SOX2 and lip and oral cavity carcinoma: Interestingly, results consistently showed that patients harboring positive expression of SOX2 (either SOX2 > 10% or SOX2any) and NANOG (either cytoplasmic or nuclear expression) significantly exhibited a much higher risk of developing oral cancer, compared to patients with positive expression of either SOX2 or NANOG or those patients with negative expression (Table 5).