Compared with cells incubated with platelets from HVs, those incubated with platelets from CRC patients exhibited higher proliferation rates (Figure 6E and 6I) and lower apoptosis rates (Figure 6F and 6G), and this promotion of proliferation and inhibition of apoptosis was attenuated by co-transfecting HT29 cells with TIMP1 siRNA. This evidence concerns the gene TIMP1 and colorectal carcinoma.