Meanwhile, the elevated expression of histone deacetylase 6 (HDAC6) have been confirmed to be involved in renal diseases including AKI [16–18], autosomal dominant polycystic kidney disease [19], and hypertensive nephropathy [20] for the contribution to inflammation, apoptosis and fibrosis. Here, HDAC6 is linked to autosomal dominant polycystic kidney disease.