In tumor tissue, chronic exposure to antigen and the development of dysfunctional or exhausted effector T cell are accompanied by high expression of one or more inhibitory receptors including PD-1, lymphocyte activation gene 3 (LAG-3), and T-cell immunoglobulin and mucin-domain containing-3 (TIM-3) [14]. The gene discussed is LAG3; the disease is neoplasm.