Based upon our methylation and expression analyses, we observed a potential functional role of hypomethylation in 12 HCV-HCC dmREs that downregulated their proximal genes (PTPRN2, SDK1, MTRR, MROH5, TSNARE1, SNTG2, MTUS2, and PRRC2A), many of which were previously associated with HCC. This evidence concerns the gene MTRR and hepatocellular carcinoma.