TP53 and neoplasm: The efficiency of such treatments also in p53-wt glioblastoma patients is of high clinical relevance as, although about 30% of patients with primary and about 60% of patients with secondary glioblastoma have mutant p53 [48, 49], intratumoural heterogeneity of p53 mutation status has been reported and is thought to trigger tumour recurrence after p53-dependent treatment [50, 51].