Further studies showed that low levels of MCPIP1 in ccRCC induce endothelial cell angiogenesis and that the lack of MCPIP1 RNase activity is responsible for the secretion of proangiogenic factors—VEGF, IL-8 and IL-6—by tumour cells [34]. The gene discussed is ZC3H12A; the disease is nonpapillary renal cell carcinoma.