IRAK1 and systemic lupus erythematosus: The miR-146a targets include several factors crucial for proinflammatory signalling (e.g., tumour necrosis factor receptor-associated factor 6 (TRAF6) and interleukin-1 receptor-associated kinase (IRAK-1)) [48], and hence, miR-146a deficiency in the white blood cells of systemic lupus erythematosus patients is correlated with upregulation of MCPIP1 expression and overactivation of inflammatory responses [46].