The CXCR4/SDF-1 axis can coordinate the metastasis of various tumours, and our observations not only demonstrate the impact of MCPIP1 on tumour angiogenesis but also highlight the role of MCPIP1 downregulation in potentiating SDF-1-CXCR4 signalling. The gene discussed is CXCR4; the disease is neoplasm.