In contrast, a significant difference was not observed in patients with HER2+/HR+ breast cancer (OR = 1.37; 95% CI, 0.88–2.13; P = 0.165) or HER2+/HR- breast cancer (OR = 1.37; 95% CI, 0.91–2.07; P = 0.123) in controlled trials (Fig. 2b). The gene discussed is ERBB2; the disease is breast cancer.