MMP8 and cancer: For the MMP-8 Lys460Thr variant, we also indicated no major association of this variant on cancer risk (C vs. A: OR = 0.94, 95% CI = 0.67–1.32, Pheterogeneity = 0.905, P = 0.729; CC vs. AA: OR = 0.83, 95% CI = 0.36–1.93, Pheterogeneity = 0.859, P = 0.669; CA vs. AA: OR = 1.00, 95% CI = 0.66–1.50, Pheterogeneity = 0.904, P = 0.994; TT + TC vs. CC: OR = 0.96, 95% CI = 0.67–1.40, Pheterogeneity = 0.886, P = 0.848; recessive model: OR = 0.83, 95% CI = 0.36–1.93, Pheterogeneity = 0.866, P = 0.669, Table 2).