The diagnostic accuracy of the VWF:Ag/ADAMTS13:AC ratio was comparable with that of AFP-L3%; nonetheless, the VWF:Ag/ADAMTS13:AC ratio is a remarkably superior diagnostic biomarker of AFP-L3% in terms of universality and objectivity and could serve as a potentially favorable biomarker for the early diagnosis of HCC in cirrhotic patients. This evidence concerns the gene VWF and hepatocellular carcinoma.