ROC analysis showed that the area under the ROC curve of AFP, DCP, AFP-L3%, VEGF, VEGFR2, ADAMTS13:AC, VWF:Ag, and the VWF:Ag/ADAMTS13:AC ratio for the early diagnosis of HCC in patients with cirrhosis was 0.61, 0.58, 0.54, 0.74, 0.67, 0.59, 0.67, 0.63, and 0.73, respectively. The gene discussed is VWF; the disease is Cirrhosis.