The scaffolding protein Dok1, a major substrate of Src and Abl, has been involved in cell proliferation and cytoskeletal rearrangements.21 Phosphorylation of Dok1 triggers Nck recruitment and filopodia formation.22 Also, studies showing inhibition of migration of B16F10 mouse melanoma cells23 by dominant‐negative mutants of Dok1 suggest a vital role of this scaffolding protein in cytoskeletal pathways controlling cells motility and invasion. This evidence concerns the gene NCK1 and melanoma.