MMPs are key players in ECM remodeling during cancer metastasis.70 Podosomes are rich in MMPs that drive matrix remodeling in various cell types.71 In a recent study, using human breast carcinoma cell line MDA‐MB‐231 and mouse model, we demonstrated that Nck facilitates MMP14‐mediated breast carcinoma cell invasion.12 In our present study, RT_PCR analysis revealed high MMP14 expression in MDA‐MB‐231 cells compared with noncancerous cells MCF‐10 and HUVEC (Figure 5B). This evidence concerns the gene NCK1 and breast carcinoma.