Nck initiates actin polymerization in invadopodia through the activation of N‐WASp/Arp 2/3 pathway in cancer cells.15, 16, 17 Previous studies show the involvement of phosphorylated Tks515 and cortactin18 in the recruitment of Nck adaptors to actin‐based invadopodia. The gene discussed is NCK1; the disease is cancer.