Ichthyosis with confetti (IWC), also termed congenital reticular ichthyosiform erythroderma (CRIE) or ichthyosis variegata (OMIM #609165), is a keratinopathy associated with dominant‐negative frameshift variants in keratin 10 (KRT10) and keratin 1 (KRT1).1, 2 Skin of affected patients demonstrates generalized erythroderma, persisting throughout life. Here, KRT1 is linked to congenital reticular ichthyosiform erythroderma.