KRT1 and striate palmoplantar keratoderma: In support of a non‐nuclear localizing signal of alanine‐rich keratin tails, frameshift variants in KRT1, leading to alanine‐rich tails, are reported to cause ichthyosis hystrix Curth‐Macklin (IHCM)15, 16 and striate palmoplantar keratoderma (SPPK).17 Keratinocytes of these patients do not display nuclear localization of aberrant K1 products.16