EGFR and cancer: Signal transduction activated by EGFR has an important role in cell motility in various types of cancer.23, 24, 25 The crosstalk between EGFR and G‐protein–coupled receptors modulates Rho GTPases activity and may contribute to the cell migration.26, 27 In cancer cells, various mechanisms may lead to permanent activation of EGFR, that is overexpression of ligands and receptors, EGFR gene amplification or activating mutations.