Secretion of proteases able to digest elements of the ECM enables cancer cells to invade through surrounding microenvironment and form metastasis.4, 5 MMP‐9 and MMP‐2 that induce degradation of the components of the extracellular matrix are particularly involved in favouring tumour cell infiltration and spreading.46, 47, 48 EGFR stimulation was demonstrated to promote squamous carcinoma cell migration and invasion via induction of EMT‐like phenotype switch and MMP‐9‐mediated degradation of E‐cadherin.49 Therefore, we also analysed proteolytic activity of generated variants of melanoma cells. This evidence concerns the gene MMP2 and melanoma.