EGF and melanoma: Their main role is secretion of proteases digesting elements of the ECM, what enables cancer cells to migrate through surrounding microenvironment.4, 5 Previously, we showed that chemoattractants—epidermal growth factor (EGF) and hepatocyte growth factor (HGF) stimulate invadopodia formation, and extracellular matrix degradation, what correlates with higher invasive abilities of melanoma cells.6