AKT1 and melanoma: In the case of melanoma, the gene expression data are inconsistent7; however, some researches postulate that overexpression of EGFR often occurs in advanced stages of melanoma.8 Following ligand binding EGFR undergoes dimerization what induces its autophosphorylation and is essential for downstream signalling pathways activation, with the most significant represented by PI3K/AKT (Phosphoinositide 3‐kinase/Protein kinase B) and MAPK (mitogen‐activated protein kinase).