Their main role is secretion of proteases digesting elements of the ECM, what enables cancer cells to migrate through surrounding microenvironment.4, 5 Previously, we showed that chemoattractants—epidermal growth factor (EGF) and hepatocyte growth factor (HGF) stimulate invadopodia formation, and extracellular matrix degradation, what correlates with higher invasive abilities of melanoma cells.6 The gene discussed is HGF; the disease is cancer.