These CD133+ lung cancer spheres exhibited self‐renewal abilities, stress/drug resistance, epithelial‐to‐mesenchymal (EMT) potential and the ability to recapitulate tumour heterogeneity in vivo.14, 15, 16, 17, 18 The drug resistance may be due to features related to the stem cell pathway, expression of high‐level ATP‐binding cassette transporters and specific surface biomarkers.19 Identifying agents to eliminate CSCs has become an important issue for anti‐cancer drug development. This evidence concerns the gene PROM1 and neoplasm.