PROM1 and cancer: CD133 and Oct‐4A, the CSC markers, have been suggested as protectors for cancer cells from apoptosis induced by chemotherapeutic agents.25, 26, 36 Significantly increased apoptosis‐related proteins—cleaved caspase‐3 and cleaved PARP—were observed in cells treated with gemcitabine plus thiostrepton (Figure 4C).