Previous studies have reported that PI3K/Akt and PLC signalling pathways play an important role in TNBS‐induced visceral hypersensitivity in rats, possibly through up‐regulating neuroreceptors such as NMDA receptors, promoting the release of SP, CGRP and other peptide transmitters, and altering neuroplasticity involved in the process of spinal sensitization to visceral hypersensitivity. This evidence concerns the gene HSPG2 and hypersensitivity.