Expression analysis of apoptosis-related proteins indicated a marked induction of anti-apoptotic BCL2 expression in the 5-FU-resistant HT-29 cells, consistent with previous studies that showed little to no expression of BCL2 in wild-type HT-29 colon cancer cells (16,17) and BCL2 stabilization in 5-FU-resistant HT-29 cells (18). The gene discussed is BCL2; the disease is malignant colon neoplasm.