Specifically, NSD3S, a short isoform of the NSD3 histone lysine methyltransferase, lacking methyltransferase activity, has been linked with progression of leukemia (Shen et al., 2015) and NUT-midline carcinoma (French et al., 2014; Suzuki et al., 2014). The gene discussed is NSD3; the disease is leukemia.