We analyzed serum and BMP4, two established biologicals known to induce glioblastoma differentiation in culture (Lee et al., 2006; Piccirillo et al., 2006; Pollard et al., 2009) and established signatures of the differentiated glioblastoma cells based on the pattern of epigenetic marks that could be applied across several genetic backgrounds. This evidence concerns the gene BMP4 and glioblastoma.