Most ISGs present in the whole blood Berry TB signature (Berry et al., 2010), the Scriba TB plasma proteome (Scriba et al., 2017) and the Naranbhai et al. ML ratio gene set (Naranbhai et al., 2015) displayed cross-species type I IFN-induction throughout mammalian evolution (Figure 6b). This evidence concerns the gene SGCG and tuberculosis.