In contrast, ISRE (STAT1/STAT2) and IRF1 motifs, the major upstream regulators observed in TB monocyte transcriptome (Figure 5a top panel) and shared between IL-6 and IFN signaling (Figure 5b), were not enriched in the ‘ML ratio’ gene set (Supplementary file 2). The gene discussed is IRF1; the disease is tuberculosis.