‘IL6/STAT3’ pathway-associated proteins such as PLA2G2A, CRP, STAT3, IL-6 and CFB increased around 12 months before TB diagnosis (Figure 5c,d, top panels - orange circles and bars), which was concomitant with significant changes in the ‘IFN/IL6-shared’ plasma markers CXCL10, IFNAR1 and MMP9 (Figure 5c,d top panels - blue circles and bars). The gene discussed is MMP9; the disease is tuberculosis.