This SNP is located in 3'UTR of vascular endothelial growth factor gene which may affect hsa‐miR‐591 target sites.186 This gene affects angiogenesis, tumor growth, and metastasis.187 It is also related to CRC outcomes and treatment.124 Thus the association between rs3025039 and CRC risk may be related to the effect of this SNP on miRNA:mRNA interactions. The gene discussed is VEGFA; the disease is neoplasm.