In a binary backward logistic regression model including age, gender, BMI, NIHSS on admission, hypertension, hyperlipidemia and PAI‐1 4G/5G genotype, PAI‐1 5G/5G genotype was revealed as a significant, independent risk factor for post‐lysis ICH (Table 6). The gene discussed is SERPINE1; the disease is hyperlipidemia.