Studies demonstrated that miR‐26b could regulate HCC epithelial‐mesenchymal transition and metastasis through targeting USP9X and SMAD1.26, 27 Li et al reported that miR‐26b could inhibit HCC cell invasion and migration by directly binding to gene EphA2.28 In addition, miR‐26b was reported to enhance the chemosensitivity of HCC cells by targeting TAK1.13 Thus, these findings suggest that miR‐26b plays a crucial role in HCC as a tumor‐suppressing miRNA. This evidence concerns the gene SMAD1 and neoplasm.