To further elucidate whether CASP11 plays a role in inflammasome activation in response to MRSA, we evaluated cleavage of CASP1 and IL‐1β in cell culture supernatants from WT and casp11−/− macrophages via Western blot analysis at 24 h post‐infection (MOI 20:1). The gene discussed is CASP1; the disease is infection.