SCAF11 and serum lipopolysaccharide activity: While CASP11 deficiency has been shown to protect mice from LPS‐induced endotoxemia due to reduced release of the inflammatory mediators IL‐1α, IL‐1β, and CXCL1/KC 5, 9, 12, the absence of CASP11 in the context of Gram‐negative bacterial infections promotes bacterial replication and dissemination in mice 8, 9, 13, 14.