Melatonin could destabilize hypoxia-inducible factor (HIF)-1α and/or suppress HIF-1α transcriptional activity in colon cancer cell [70], resulting in a reduction in the expression of vascular endothelial growth factor (VEGF), which functions as the most important angiogenesis growth factor that promotes cancer progression [71, 72]. The gene discussed is HIF1A; the disease is malignant colon neoplasm.