TYRP1 and melanoma: Indeed, Büll et al. have shown that encapsulation of 3Fax-Neu5Ac in poly(lactic-co-glycolic acid) (PLGA)-based nanoparticles (NPs) targeting the melanoma antigen tyrosinase related protein-1 (TRP-1) allowed specific and prolonged blockade of sialic acid expression in vitro and precluded metastatic spread in vivo (Bull et al., 2015).