This chemokine also plays a role in adhesion and possibly retention of MM in the BM via α4β1-dependent adhesion on fibronectin and vascular cell adhesion molecule 1 (VCAM-1) (Gazitt and Akay, 2004; Parmo-Cabanas et al., 2004; Menu et al., 2006). This evidence concerns the gene FN1 and Miyoshi myopathy.