Indeed, many reports have observed notably altered immune cell densities and cytokine profiles during CRC development (13–21), in which significantly increased CD4 and CD8-positive T lymphocyte populations are observed (22–24), along with decreased expression levels of TH1 cytokines and increased expression levels of TH2 cytokines in patients with CRC (7, 8, 25, 26). The gene discussed is CD4; the disease is colorectal carcinoma.